Phaeodactylum tricornutum as Fucoxanthin Biofactory Model and Hepatoprotective Effect of Encapsulated Spirulina and Fucoxanthin

In recent decades, the worldwide production of microalgae has been carried out on an industrial scale. years, market for natural products grown because changes in consumer preferences more products. The objective this study was to demonstrate hepatoprotective capacity fucoxanthin extract obtained from culture Phaeodactylum tricornutum (Culture Collection Alga and Protists Scotland). microalga artificial seawater mixture (1:9), using Walne’s medium columns raceway photobioreactors (RWP) inside a greenhouse. carotenoid content tested systems continued increase day 5 culture, when stationary phase reached. final biomass powder contained 4.9 mg (2.59%) pure fucoxanthin. possible activity then studied HepG2 cell line 24 h compared with cytotoxicity methotrexate (MTX). conclusion, active ingredient showed against MTX human hepatocyte HEPG-2 at concentration 0.25 mg/mL. current results also suggest that it beneficial properties liver health is suitable all types nutraceutical